Neurophysics is the branch of neuroscience dealing with the development and use of theoretical concepts and experimental tools typically employed in physics in order to gain information about the nervous system.

The Berg group put emphasis on strong quantitative approaches in neuroscience by including computational neuroscience. In particular, we believe investigating populations of neurons, networks, as opposed to the single-neuron tradition, is crucial. In turn, this will likely spur therapeutic strategies for individuals with neurological conditions, especially spinal cord injuries. Our key research areas are:

  • Neuronal Population activity in the spinal cord and brain using large array electrophysiology.
  • Development of novel probe technology
  • Classification of network architecture in motor circuits.
  • Histological clearing techniques for large sample imaging for network reconstruction
  • In vivo, awake electrophysiology with chronic implantation of electrodes and optical fibers in the central nervous system. 
  • Computational neuroscience 

Technological achievements

Designed the Berg64-probe now sold at Neuronexus, 


Awake, behaving rodents, as well as anesthetized and in vitro preparations, are used as a part of our ongoing research.  Our technical expertise includes:

  • intracellular recording
  • in vivo multisite extracellular recording
  • design and fabrication of micro electrode arrays
  • juxtacellular staining with paraformaldehyde fixable lipophilic dyes
  • intracortical electrical, pharmacological, and optical (optogenetic) microstimulation
  • brain bow labeling
  • viral expression and tracing
  • 3D histology including tissue clearing and immunochemistry analytical and numerical methods for data analysis
  • MRI and diffusion tensor imaging
  • single cell and network modeling
  • synaptic conductance estimation
  • simple behavioral test by rodents
  • treadmill locomotion
  • video monitoring and analysis of animal behaviors

Key Publications

  • H. Lindén, P.C. Petersen, M. Vestergaard, Rune W. Berg “Movement is governed by rotational neural dynamics in spinal motor networks”, Nature 610 (7932), 526-531 (2022) (DOI)
  • M. RadosevicA. WillumsenP. C. PetersenH. Lindén, M. VestergaardR. W. Berg, “Decoupling of timescales reveals sparse convergent CPG network in the adult spinal cord” Nature Communications, 10:2937, 2019, (Link)
  • R. W. Berg, A. Willumsen, H. Lindén “When networks walk a fine line: Balance of excitation and inhibition in spinal motor circuits” Current Opinion in Physiology, 8: 76-86, 2019 (Link(PDF)
  • Petersen, PC and RW Berg (2016) Lognormal firing rate distribution reveals prominent fluctuation-driven regime in spinal motor networks eLife; 10.7554/eLife.  (Link)
  • R. W. Berg, A. Alaburda and J. Hounsgaard (2007) Balanced inhibition and excitation drives spike activity in spinal half-center” Science, vol. 315(5810) 390-393. (DOI)(pdf)